in reply to: queries regarding local erythropoietin injection in tibiofibular fracture healing

Queries Regarding Local Erythropoietin Injection in Tibiofibular Fracture Healing

We would like to congratulate Dr. Bakhshi and colleagues for being the first group to publish scientific evidence regarding the osteogenic effect of erythropoietin (EPO) in a clinical trial (1). As you correctly report, several preclinical studies have shown the efficacy of Erythropoietin to increase bone healing at early time points (2-4).In agreement with your approach, we strongly believe th...

queries regarding local erythropoietin injection in tibiofibular fracture healing

In Reply to: Queries Regarding Local Erythropoietin Injection in Tibiofibular Fracture Healing

In replyWe would like to thank Dr. Duedal Rölfing for his keen observations. We hope that this study encourages prospective scientific publications. Erythropoietin (EPO) is a glycoprotein produced by the kidney which promotes the formation of red blood cells in the bone marrow. Recent studies have determined additional roles of EPO in tissue survival and cellular proliferation (1-3). EPO may ac...

Local Erythropoietin Injection in Tibiofibular Fracture Healing

BACKGROUND Erythropoietin (EPO), in addition to its function as an erythropoiesis regulator has a regenerative activity on some nonhematopoietic tissues. Animal studies have suggested a role for erythropoietin in bone healing. OBJECTIVES The present study aimed to evaluate the effects of local EPO injection in healing of tibiofibular fractures. MATERIALS AND METHODS In a prospective double ...

local erythropoietin injection in tibiofibular fracture healing

conclusions epo injection into the site of tibiofibular fractures may possibly accelerate healing. background erythropoietin (epo), in addition to its function as an erythropoiesis regulator has a regenerative activity on some nonhematopoietic tissues. animal studies have suggested a role for erythropoietin in bone healing. objectives the present study aimed to evaluate the effects of local epo...

Potential Role of Local Estrogen in Enhancement of Fracture Healing: Preclinical Study in Rabbits

      Background: Effects of estrogen on bone metabolism and its protective role on prevention of osteoporosis are well   documented. However, the efficacy of estrogen treatment on bone healing is not well investigated. The drug can be delivered both systemically or locally to the bone with differences in concentrations and side effects. The aim of this study was to investigate the effect of lo...